However silly it may sound, look odd, or even seem cuckoo, escargots provide an unparalleled solution for scar treatment, plus a myriad other skin benefits...

A screen for natural products bearing pharmacological properties has yielded a secretion of the gastropod Cryptomphalus aspersa (SCA), also popularly known as escargot, which possesses skin-regenerative properties.

The report, published in the January 2008 Skin Pharmacology & Physiology, the Journal of the International Society of Pharmacological and Biophysical Research outlines some of the cellular and molecular effects underlying this observation and the secretion's many benefits for human skin.

First, the secretion contains antioxidant SOD and GST activities. In addition it stimulates fibroblast proliferation and rearrangement of the actin cytoskeleton. Additional mechanisms involved in its regenerative effect include the stimulation of extracellular matrix assembly and the regulation of metalloproteinase activities.

Together, these effects provide an array of molecular mechanisms underlying the secretion's induced cellular regeneration and support its use in regeneration of wounded tissues.

Link: Skin Regeneration Properties of Mollusk Secretion Copyright © 2007 S. Karger AG, Basel

Cutaneous aging is the result of a complex process where genetics as well as chronological and environmental factors (particularly UV radiation) are involved. Skin aging manifests as wrinkles, diminished structural integrity and impaired wound healing due to alterations in the remodeling process of the extracellular matrix (ECM). Collagen and elastin impart strength and their degeneration with the passing of time causes skin to become fragile, and aged in appearance [1–4] .

Many factors can affect skin regeneration. The presence of pathogens in the lesion may impair regeneration, and other factors such as reactive oxygen species can also play a negative role in this process [5] . In addition, dermal fibroblasts must proliferate and migrate into the injured tissue, covering the lesion and manipulating the ECM (‘matrix remodeling’) to ensure scar formation and promote healing, a process compromised by skin aging [6] .

The search of substances with regenerative properties has led many pharmaceutical companies to develop extensive search programs aimed to identify natural products that can induce skin regeneration or stimulate natural regeneration.

In this regard, it has been noted that escargots perceive radiation, retract their orientation organs, and secrete large amounts of mucous substances as a defensive response in order to protect themselves from harmful radiation.

In addition, escargots never suffer from skin infections, which directed researchers attention to the possibility of using this secretion as a possible treatment of skin-compromising diseases.

In this regard, an early study showed that a secretion from the mollusk Cryptomphalus aspersa (SCA) induces skin regeneration after wound healing impairment from acute radiodermatitis [7] . However, the molecular basis underlying this effect were unknown.

The researches responsible for this report evaluated the regenerative properties of SCA using multiple in vitro approaches. They found that SCA possesses antioxidant capabilities and induces fibroblast proliferation. A complementary mechanism is provided by the fact that SCA promotes ECM assembly, which is essential for wound healing and tissue plasticity. Finally, SCA inhibits MMP production, which limits the extent of the damage during wounding and scar formation. Together, these mechanisms contribute to the observed beneficial effects of SCA and support its employment in regenerative therapy.

Fig. 1. Antioxidant properties of SCA. ABTS assay was carried out
adding SCA (100 µg/ml), quercetin (2.5 µM ), Trolox C (10 µM ) or
vehicle alone at 300 s (arrow); absorbance at 743 nm was measured
at the time points indicated. Mean ± SEM of three independent
experiments performed in triplicate are shown.

Fig. 2. SCA promotes fibroblast proliferation. Human dermal fibroblasts
from healthy donors were incubated with the indicated
doses of SCA in the presence or absence of 0.1 mM citrate pH 5.0.
Cells were cultured in these conditions for a week and then cell
numbers were determined spectrophotometrically by crystal violet
staining. Data are referred to cells cultured in medium in the
absence of SCA or other additives. Mean ± SEM of three independent
experiments performed in triplicate are shown.

Results

Antioxidant Properties of SCA
To determine if SCA possessed antioxidant properties, SCA was asssayed for different antioxidant activities. The assays revealed that SCA cannot antagonize cytochrome C oxidation (data not shown), but possesses superoxide dismutase (SOD) as well as GST activities (4.1 ± 2.1 and 3.4 ± 1.5 U/ml, respectively). SOD is a key enzyme during inactivation of the superoxide anion (O₂ ) radical and hydrogen peroxide (H₂ O₂ ) [8] , whereas GST is a typical phase 2 enzyme responsible for detoxification of both ROS and electrophilic xenobiotics [9] .

In addition, the capability of SCA to scavenge free radicals was assayed by the ABTS method ( fig. 1 ). It was found that SCA sequestrates ABTS⁺ , the free radical generated in the assay more potently than 10 µM Trolox C, used as a positive antioxidant control. In addition, SCA also inhibits the production of ABTS⁺ , as determined by the slope of the absorbance curve ( fig. 1 ). The extent of the inhibition was more extensive to that exerted by 2.5 µM quercetin. Together, these data demonstrate that SCA possesses multiple modes of antioxidant action, acting at the level of free radical production and also sequestering free radicals.

SCA Induces Fibroblast Proliferation in vitro and Regulates Fibroblast Cytoskeleton Reorganization
To investigate if the regenerative properties of SCA are related to enhanced cell proliferation, the authors assayed its effect on fibroblast proliferation in vitro. Interestingly, SCA increased cell proliferation, which was further enhanced by addition of citrate, which has been shown to induce fibroblast proliferation [10]. This result was further reinforced by the fact that SCA increased cell survival upon irradiation with UVA light, which suggests that the observed beneficial effect of SCA is due to combined antioxidant and proliferative activities. In addition, SCA affects the morphology of human dermal fibroblasts, inducing actin reorganization, bundling and microfilament alignment, which results in cell elongation.

SCA Stimulates Fibronectin Secretion and Assembly
Since ECM assembly is a key event in tissue regeneration, the putative effect of SCA in this process was assayed. CHO-K1 cells were cultured on either untreated or 5 µg/ml human fibronectin in the presence of two different doses of SCA, and fibronectin assembly was monitored after 24 h by indirect immunofluorescence.

Researchers found that SCA induced fibronectin assembly compared to control cells. Interestingly, SCA seemed to increase fibronectin secretion since it increased fibronectin deposition by the cells in the absence of exogenous fibronectin. To demonstrate that the increase of fibronectin was not due to fibronectin present in the secretion, SCA was analysed by ELISA and Western blot using a panel of antibodies anti-fibronectin; included that used for the experiments.

SCA contained no fibronectin reactivity using any of the antibodies used neither by Western blot nor by ELISA. This demonstrates that the observed effect of SCA in fibronectin assembly and secretion is due to its effect on the cells, not on direct deposition of ECM included in the extract.

SCA Downregulates Matrix Metalloproteinase Expression in Dermal Fibroblasts
Increased metalloproteinase expression has been associated to impaired wound healing and regeneration. To investigate if SCA enhanced regeneration through the regulation of metalloproteinase expression, MMP expression was assayed by dermal fibroblasts in the presence of different concentrations of SCA. SCA significantly inhibited MMP-1 and MMP-2 expression, suggesting that limitation of MMP expression contributes to its regenerative properties.

Discussion
SCA is a natural secretion from the mollusk C. aspersa that bears regenerative properties in experimental acute radiodermatitis produced in a rat model [7] . Furthermore, SCA application twice daily for 3 months also results in a significant improvement of clinical and histopathological photoaging signs [5] . However, the molecular foundations of the beneficial effect of SCA remained unknown. The cited report shows in vitro analysis of several possible contributions to the physiological effect of SCA. First, it was found that SCA bear antioxidant activities as well as free radical scavenging capability. The role of oxidation in wound healing is controversial [11] , but there is a clear correlation between enzymatic and non-enzymatic cutaneous antioxidants and its protection from ROS-mediated skin damage induced by UV radiation. Indeed, UV radiation can decrease endogenous antioxidant levels and lead to increased damage [12] . In these cases, antioxidant compounds can modulate abnormal remodeling after trauma or prevent or reverse clinical signs associated with photoaging secondary to ROS.

In addition, SCA promotes fibroblast survival and proliferation. Proliferation is essential for wound healing, since the formation of the scar relies not only on cell migration (i.e. invasion of the wound by border cells), but also on cell proliferation to replenish the tissue zones that provide the migrating cells invading the wound. The effect of SCA was similar to that observed in dermal fibroblasts treated with bFGF [13] . Thus, it was hypothesized that SCA might contain an FGF like activity responsible for fibroblast proliferation.

However, the fact that the secretion belongs to a mollusk impaired the analysis of bFGF, since the only kits for mammalian FGFs are currently available, and these did not recognize any FGF-like activity in SCA (data not shown). Thus, the researchers devised an indirect strategy, adding well-characterized stabilizers and enhancers of bFGF to SCA to modulate its effect on proliferation. These included citrate [14–16] , which had no effect when added to the cultures alone (data not shown). However, in conjunction with SCA, it boosted its pro-proliferative effect, suggesting that citrate enhanced the putative FGF like activity contained in SCA.

It was also found that SCA increases ECM assembly when added alone or in conjunction with exogenously added fibronectin. This is a very important phenomenon during wound healing since matrix remodeling is a key step in fibroblast motility for wound healing and scar formation.

In fact, matrix secretion and rearrangement is absolutely required during in vitro wound healing assays, since scratching the surfaces also depletes ECM from the wound, which is required for lamellipodial extension and net cell migration into the wound. The first obvious conjecture was that SCA contained fibronectin. However, none of the antibodies assayed against fibronectin recognized any component of SCA. However, this provided an excellent internal control since these antibodies could not detect SCA added to the cultures, and increases observed are likely to be due to increased fibronectin expression and/or secretion by the cultures. Indeed, bFGF has been shown to increase fibronectin fibrillogenesis [17] . The effect of SCA on fibronectin assembly seems more dramatic as shown by enhanced bundling of fibronectin fibers, but its effect on secretion cannot be ruled out without more experimentation, which is underway in the researchers laboratory.

Another possible mechanism for fibronectin remodeling was an increase in integrin activation induced by SCA. Indeed, integrin activation has been linked to matrix remodeling [18] . However, SCA did not activate ß1 integrins by itself nor did it affect Mn ²⁺ -induced conformational changes, as determined by the use of HUTS-21, a conformation-dependent antibody (data not shown). This result suggests that the effect of SCA on ECM assembly relies on mechanisms other that integrinfibronectin binding.

Finally, SCA has been shown to slightly inhibit the expression of MMP-1 and MMP-2.

ECM proteinases are upregulated during wound healing and scar formation, and they are believed to be essential for wound closure and scar formation [19, 20] . This effect of SCA is apparently at odds with the fact that bFGF enhances MMP-1 and MMP-2 expression [21, 22] . We speculate that this apparent contradiction can be explained by SCA containing at least two active principles, an FGF-like activity and an inhibitor of MMP expression. Alternatively, SCA could enhance the expression of TIMPs (tissue inhibitor of metalloproteinases). This can also help explaining this dual effect of SCA, since bFGF has been shown to inhibit or increase TIMP expression depending on the cell model [23–25] . This is a very interesting topic, and the presence of TIMP-like molecules; stimulation of TIMP expression or the presence of other non-related MMP inhibitors in SCA is being currently studied in the laboratory.

Together, the data provides evidence for the molecular mechanism underlying the observed regenerative effect of SCA and open an interesting avenue of research aiming to clarify these effects and isolate the active principles responsible of the effects herein described.

The skin cream presented at this website and made with the escargot serum is designed to gently ditch out damaged cells of your skin regularly. Not only will you slough off that dulling, dead, outermost layer of skin that is less than a micron thick, regularly. But, you will keep the circulation flowing in your body alive, which will rejuvenate you and your skins vibrancy.

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Bioskincare is a 100% pure skin cream that regenerates your skin and also works to keep it moisturized, vigorous, smooth, kissable and rescilient. It provides results on the appearance of fine lines, wrinkles, redness, acne, dark sun spots, facial blemishes, – even acne scarring, surgical scars and body stretch marks that you have lived with a long time will appear softer and be less noticeable. This skin cream mobilizes your body's own healing resources to maximize the effectiveness of the biological ingredients it supplies.

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BIOSKINCARE is made with the ONLY all-natural ingredient found in NATURE created by little land escargots that are abundant in most vineyards, and use it themselves to repair their skin whenever damaged and to trigger the proliferation of antimicrobail peptides to avoid beeing affected by attacks from opportunistic micro-organisms always ready to intrude when skin is injured. Now, isn't that truly amazing! As a result, escargots never suffer from skin infections – can you imagine?

Escargots also use it to moisturize, repair, renews and protect their skin while they thrive exposed nude to the sun rays and the hazards of the environment, pretty much like we merry around exposing our nude face. It is also the mechanism they use to protect their body from oxygen radicals when they go out of their shell after hibernating and from the damaging effects of solar radiation.

Land escargots crawl over a variety of potentially contaminated surfaces and the escargot foot could be the primary site of entry for pathogens, parasites and a range of opportunistic organisms, so it is not much wonder they must have a defensive system to protect them. Such mechanism is a silvery secretion they produce whenever they are under stress and different than the one they leave behind while crawling.

Since the 19th century there has been a renewed interest in the pharmaceutical and medical use of escargots, particularly for dermatological applications.

But the most common purpose for raising escargots in modern times has been for food. That is, until a escargot farm in Chile noticed that their escargot handlers had exceptionally smooth hands, and any cuts or abrasions to their hands healed unusually quickly and without scars.

Scientific screening of the components of the escargot's threapeutic fluid has shown it contains peptides that form pores in microbial membranes and disrupt their integrity while at the same time they trigger skin regeneration. The fluid is a biological complex compound of glyco or sugar chain molecules bound to proteins, peptides, enzymes, coenzymes and Copper, Calcium, Zinc and Iron present in nanomolecular amounts as trace oligoelements. Using proprietary technology, no harm is inflicted upon the escargots during the collection process.

Screening also shows that the skin of these little creatures is made of the same structures present in human skin: — the same collagen and elastin connective tissues, and the same water holding glycosaminoglycan and proteoglycan molecules, etc.—. No wonder it works so well for a large array of those bothersome skin afflictions we humans suffer from.

BIOLOGICAL NATURAL SKIN CARE

Nature's gift for healthy skin ™

The escargot' secretion is a complex compound of powerful water soluble proteoglycans, glycosaminoglycans, protein enzymes, copper peptides, antimicrobial peptides and Copper, Zinc, Calcium and Iron oligoelements. And although highly valued by medical scientists and the cosmetic industry for their biological activity it has not been possible to synthesize them in even the most sophisticated biotechnological laboratory.

The fluid is the most original, complete and balanced solution for skin care created by a living creature to protect, restore integrity without leaving scars behind, renew and moisturize its own skin (its own collagen, elasting, water holding molecules and other skin structures which are very much the same human skin is made of).

It acts on human skin as a biological activator of both the elimination of dead and damaged skin cells and the orchestrated renewal of all the elements of healthy skin. It is also antioxidant. And controls folliculitis of the skin and scalp (infection) and facial and body acne.

SKIN CARE FROM DIFFERENT PERSPECTIVES
Dermatologists say BIOSKINCARE performs three coordinated functions:

1) supports your immune system and helps it recognize non functional and damaged tissues

2) degrades the disfunctional, damaged, dying or dead tissues into their basic amino-acid and other components and releases them for regeneration of healthy skin cells and

3) orchestrates the reconstruction of all the components of the skin matrix by triggering the proliferation of all its healthy structures.

A cosmetic formulator would tell you the biological ingredient in BIOSKINCARE™ is a balanced and complete solution for skin care. Protects, repairs, renews and moisturizes the skin.

Scientists engaged in the development of new knowledge in the newest branch of biological sciences, the science of glycobiology, say the fluid secretion is made of complex molecular conjugates: glycoproteins, sulfated acidic glycosaminoglycans, proteoglycans, enzymes and coenzymes. These are molecules of particularl importance for effective communication among cells. They play a crucial role in transmitting important biochemical signals into and among cells. In this way, these carbohydrates (sugars) guide the cellular communication that is essential for normal cell and tissue development and physiological function.

Glycobiology is a relatively new branch is science (1988) that attempts to understand how sugars in the body -called glycans- contribute to human health and contain information as necessary to define the complexity of life as that of DNA and proteins.

From the consumer’s perspective:

BENEFITS OF THE BIOLOGICAL INGREDIENT BASED ON SCIENTIFIC EVIDENCE

1) Removes dead, dying and denatured skin cells. It does so by the action of enzyme digestion (dissolution by hydrolysis) which reduces blemishes, gently dissolves plugs of clogged pores, imperfections, scars, stretch marks, and keratosis on the surface of skin instead of aggresively polishing them out as exfoliation or glycolic acid chemical peels do.

2) Promotes cell proliferation and new synthesis of collagen, elastin, and the water holding molecules within the skin (hyaluronic acid and other glycosaminoglycans).

Collagen provides strength, elastin the elasticity, and glycosaminoglycans and proteoglycans the moisture and plumpness of the skin. With aging, the thickness of the dermal layer is reduced and this is partially responsible for the formation of wrinkles in aging skin.

3) Helps remodel and speed turnover of the basal membrane of the skin

4) Antioxidant - provides protection from the effects of UV radiation and free radicals: photo-protective action.

Specific studies show the following antioxidant activities in the biological ingredient:
a) enzymatics as superoxide dismutase (SOD), b) conjugation enzymes as glutathione-S-transferase and c) low molecular weight antioxidants.

Antioxidant activities benefit the cells in the skin by:
• Inhibiting Reactive Oxygen Species (ROS) generation and free radical sequestration effects.
• By protecting the cells against UVA radiation, with double the antioxidant activity of Quercetin Flavonoids and Troloc C, a water-soluble vitamin E analog, used as control antioxidants in this type of studies.

5) Breaks down denatured proteins into its amino-acid components, which otherwise cause inflamm-aging, and releases those for rebuilding of the skin structures.

6) Hydrates the skin from within because it promotes the proliferation of glycosaminoglycans, the molecules that hold in water in the skin. This strengthens and firms the skin, thus preventing tearing of skin that may show as stretch marks and avoiding sagging.

BIO SKIN CARE™ products combine nature's wisdom with a biotechnology that stabilizes and protects the glycoconjugates from degrading by placing them in liposomes, which secures their bioavailability and proper release deep within the skin.

BIOSKINCARE CREAM - ORGANIC FORMULA WITH NATURAL INGREDIENTS
BIOSKINCARE™ is formulated to transform a complex substance that is an antioxidant fluid with cell-communicating ingredients and biological activators of skin renewal into a natural skin cream. A treatment cream that also moisturizes, replenishes and stabilizes the lipid content within the intercellular skin matrix.

This is achieved by adding natural emollients, emulsifiers, surfactants and nourishing extracts derived from Olive Oil, hydrating Hyaluronic acid, and humectant Glycerin.

The Olive Oil derivatives in the formulation make the liquid biological ingredient into a cream, especially Squalene -which is also an antioxidant-, and replenish the lipid barrier of the skin.

Hyaluronic Acid, Glycerin, and Squalene in the cream contribute to your skin’s hydration and have long term effects on the capacity of skin to hold in water.

HEALTHIER & BEAUTIFUL ROUTINE
Apply on clean and pat dry skin twice daily. More is not necessarily better, but to ensure optimum results application on older blemishes or more affected areas should be repeated more frequently. Results are cumulative and become permanent.

Use the cream as a belly balm to prevent stretch marks from the third month of pregnancy and continue for three months after child birth. See further below our offer for the BIO STRETCH MARK CREAM, which is the same as BIOSKINCARE in a larger container and with a twist that is better suited for pregnancy and to simultaneously get rid of cellulite.

Use BIOSKINCARE™ on raised hypertrophic scars or on stretch marks in conjunction with strong massage and exfoliation to eliminate dead skin cells or try our new BIOSKINEXFOL cream to break down old and rough stretch marks presented in the section on new products further below.

Apply BIOSKINCARE™ on keloids after cleansing with a salicylic pad. Use on dry face after washing the face with lukewarm water for the relief of rosacea or skin rashes. Use it after shaving to prevent and heal ingrown hairs and razor bumps.

BIOSKINCARE ™ is recommended for use before and after skin resurfacing procedures such as chemical peels, dermabrasion, micro-dermabrasion or laser surgery.

The cream is also a unique nutrient-rich moisturizer for wrinkles on the face, the delicate eye area, neck, and body. It promotes balanced skin renewal. Treatment should be continued until desired results are achieved. Or, try our new BIO SKIN REJUVENATION cream to even your skin tone and get rid of age spots.

When applying BIOSKINCARE CREAM to get rid of acne dab it on your face twice a day on the whole face, not only on the pimples, whiteheads or blackheads. You can also use it safely n conjunction with acne drugs to avoid their side effects. If your skin is too oily and you wish to use an oil free product try our BIOSKINCLEAR oil free gel, with soothing seaweed extract, for people with very oily skin that suffer from acne or rosacea.

All our products are safe for children and moms-to-be. The cream relieves baby's diaper rash & eczema and softens and moisturizes rough areas on knees and cracked feet.

References
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22 Kenagy RD, Hart CE, Stetler-Stevenson WG, Clowes AW: Primate smooth muscle cell migration from aortic explants is mediated by endogenous platelet-derived growth factor and basic fibroblast growth factor acting
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Get rid of scars, redness, keratosis, mild & moderate acne blemishes, skin dryness, rashes and more... Hydrate, protect, repair and renew your skin to make it again lovely with BIOSKINCARE

Boosts the production of antimicrobials, unclogs pores and deeply moisturizes skin while replenishing the lipid barrier of the skin. Triggers the regeneration of damaged cells. Prevents ingrown hairs, heals nicks and cuts, and removes razor bumps, acne scars, keratosis, and all types of skin blemishes.

BIOSKINCARE Benefits

Made in the USA. One Month's supply 50 grams = 1.76 oz

50 Gram Bottle: $59.98

Save at least 20% off price & save on domestic or world wide shipping costs
when you order more than one month's supply

Discount Price Two Bottles: $47.98 each, at checkout within our secure shopping cart.

Ultra Exfoliate Your Skin with BIOSKINEXFOL

Home microdermabrasion cream. Results are not only immediate, but compound over time and do not trigger inflamm-aging of delicate skin tissues. Best for aged skin, actinic keratosis scales, raised hypertrophic scar treatment and rough stretch marks or ice-pick and old acne scars. Not for keloids. Contains the same natural ingredients in BIOSKINCARE™ but infused with micro-crystals so that you may rub it, with your finger tips to remove old, hard and tough scars or stretch marks by a physical breakdown of the scar tissues. Enzymes in the cream liquefy damaged proteins more thoroughly and helps to release amino-acids that aid to rebuild damaged tissues quickly.

Microdermabrasion Benefits

Made in the USA. Two to Three Month's supply 120 grams = 4.23 oz

120 Gram Bottle: $79

Get Rid Of Sun & Age Spots While Revitalizing and Protecting the Skin From The Effects of Free Radicals

A deeply moisturizing natural skin care cream that replenishes the lipid barrier of the skin and triggers the repair of cells damaged by UV radiation and Free Radicals. Also gets rid of brown, sun and age spots, actinic keratosis scales and all types of skin blemishes. The same ingredients in BIOSKINCARE with an added natural substance that reduces melanin hyperpigmentation and a biomimetic peptide that inhibits the accumulation of melanin pigments.