It is based on a naturally occurring immune serum produced by escargots, land snails of the species Helix Aspersa Müller.
However silly it may sound, look odd, or even seem cuckoo, escargots provide an unparalleled solution for scar treatment, plus a myriad other skin benefits... because the immune serum secreted from within the immune cells of this snail regenerates healthy skin cells and tissues... and allows you to go on with a normal life.
The immune serum helps to:
● Release scar contractures
● Reduce post burn or accidental or post surgery keloid scars and hypertrophic scarring
● Strengthen fragile tissues affected by atrophic conditions (skin that tears or bruises easily)
● Improve the quality of graft texture and color match and of scar pigmentation
The serum helps to prevent and reduce all types of scars, including hypertrophic scars and keloid scars, because it is instrumental in "orchestrating" an orderly repair of damaged skin, scar less healing & enhanced skin regeneration.
The following report, published in the January 2008 Skin Pharmacology & Physiology, the Journal of the International Society of Pharmacological and Biophysical Research outlines some of the cellular and molecular effects underlying this observation and the secretion's many benefits for human skin.
First, the secretion contains antioxidant SOD and GST activities. In addition it stimulates fibroblast proliferation and rearrangement of the actin cytoskeleton. Additional mechanisms involved in its regenerative effect include the stimulation of extracellular matrix assembly and the regulation of metalloproteinase activities.
Together, these effects provide an array of molecular mechanisms underlying the secretion's induced cellular regeneration and support its use in regeneration of wounded tissues.
Rather than take our word for it, read the actual study about the regenerative properties of the secretions, or serum, on the website of the Journal of Skin Pharmacology and Physiology Copyright © 2007 S. Karger AG, Basel.
You can also click here to see the same research as one of the authors is from the Dermatology Services of The Memorial Sloan-Kettering Cancer Center in New York, one of the most prestigious in the world.
That publication confirms previous research done in Spain that claims the secretion of land snails of the species Cryptomphalus Aspersa or Helix Aspersa Müller posses skin-regenerative properties.
Stimulates fibroblast proliferation and rearrangement of the dynamic structures of cells (the actin cytoskeleton).
A recent study, published in April 2012, by The Memorial Sloan-Kettering Cancer Center concludes that the "secretion of the mollusc Cryptomphalus aspersa promotes proliferation, migration and survival of keratinocytes and dermal fibroblasts in vitro"
It has superoxide dismutase (SOD) and glutathione-S-transferase (GST) antioxidant activities as well as other multiple modes of antioxidant action, acting at the level of free radical production and also sequestering free radicals.
Additional mechanisms involved in the regenerative effect of the mollusk's secretion include the stimulation of extracellular matrix assembly and the regulation of metalloproteinase enzyme activities, which limits the extent of the damage during wounding and scar formation.
Together, these effects provide an array of molecular mechanisms underlying the secretion's induced cellular regeneration and support its use as a skin regenerative treatment product that reduces sacarring and radiation burns and other burn-induced skin alterations.
This study has evaluated the efficacy of Helix aspersa extract in an open wound management protocol for deep partial thickness (PT) facial burns and compares it to moist exposure burn ointment (MEBO).
Conclusion: Helix aspersa extract is a natural, safe and effective alternative treatment in open wound management of partial thickness burns in adults.
Cutaneous aging is the result of a complex process where genetics as well as chronological and environmental factors (particularly UV radiation) are involved.
Skin aging manifests as wrinkles, diminished structural integrity and impaired wound healing due to alterations in the remodeling process of the extracellular matrix (ECM). Collagen and elastin impart strength and their degeneration with the passing of time causes skin to become fragile, and aged in appearance [1–4] .
Many factors can affect skin regeneration. The presence of pathogens in the lesion may impair regeneration, and other factors such as reactive oxygen species can also play a negative role in this process [5] . In addition, dermal fibroblasts must proliferate and migrate into the injured tissue, covering the lesion and manipulating the ECM (‘matrix remodeling’) to ensure scar formation and promote healing, a process compromised by skin aging [6] .
The search of substances with regenerative properties has led many pharmaceutical companies to develop extensive search programs aimed to identify natural products that can induce skin regeneration or stimulate natural regeneration.
In this regard, it has been noted that escargots perceive radiation, retract their orientation organs, and secrete large amounts of mucous substances as a defensive response in order to protect themselves from harmful radiation.
In addition, escargots never suffer from skin infections, which directed researchers attention to the possibility of using this secretion as a possible treatment of diseases the compromise the skin.
An early study showed that a secretion from the mollusk Cryptomphalus aspersa or Helix aspersa induces skin regeneration after wound healing impairment from acute radiodermatitis [7]. However, the molecular basis underlying this effect were unknown.
The researches responsible for this report evaluated the regenerative properties of the secretion using multiple in vitro approaches. They found that it possesses antioxidant capabilities and induces fibroblast proliferation. A complementary mechanism is provided by the fact that the secretion promotes ECM (Extra Cellular Matrix) assembly, which is essential for wound healing and tissue plasticity. Finally, the secretion inhibits MMP production (enzymes that degrade the skin matrix), which limits the extent of the damage during wounding and scar formation.
Together, these mechanisms contribute to the observed beneficial effects of the snail secretion and support its use in regenerative therapy.
Results
Antioxidant Properties of Snail Secretions
To determine if the secretion possessed antioxidant properties it was assayed for different antioxidant activities. The assays revealed that the secretion cannot antagonize cytochrome C oxidation, but possesses superoxide dismutase (SOD) as well as GST activities.
SOD is a key enzyme during inactivation of the superoxide anion (O2 ) radical and hydrogen peroxide (H2 O2 ) [8] , whereas GST is a typical phase 2 enzyme responsible for detoxification of both ROS and electrophilic xenobiotics [9] .
In addition, the capability of the secretion to scavenge free radicals was assayed by the ABTS method. It was found that the secretion sequestrates ABTS+ , the free radical generated in the assay more potently than 10 µM Trolox C, used as a positive antioxidant control. In addition, it also inhibits the production of ABTS+ , as determined by the slope of the absorbance curve. The extent of the inhibition was more extensive to that exerted by 2.5 µM quercetin. Together, these data demonstrate that the secretion possesses multiple modes of antioxidant action, acting at the level of free radical production and also sequestering free radicals.
Snail Secretion Induces Fibroblast Proliferation in vitro and Regulates Fibroblast Cytoskeleton Reorganization
To investigate if the regenerative properties of the secretion are related to enhanced cell proliferation, the authors assayed its effect on fibroblast proliferation in vitro. Interestingly, the secretion increased cell proliferation, which was further enhanced by addition of citrate, which has been shown to induce fibroblast proliferation [10]. This result was further reinforced by the fact that the secretion increased cell survival upon irradiation with UVA light, which suggests that the observed beneficial effect of the secretion is due to combined antioxidant and proliferative activities. In addition, the secretion affects the morphology of human dermal fibroblasts, inducing actin reorganization, bundling and microfilament alignment, which results in cell elongation.
Snail Secretion Stimulates Fibronectin Secretion and Assembly
Since ECM assembly is a key event in tissue regeneration, the putative effect of the secretion in this process was assayed. CHO-K1 cells were cultured on either untreated or 5 µg/ml human fibronectin in the presence of two different doses of the secretion, and fibronectin assembly was monitored after 24 h by indirect immunofluorescence.
Researchers found that the secretion induced fibronectin assembly compared to control cells. Interestingly, the secretion seemed to increase fibronectin secretion since it increased fibronectin deposition by the cells in the absence of exogenous fibronectin. To demonstrate that the increase of fibronectin was not due to fibronectin present in the secretion it was analyzed by ELISA and Western blot using a panel of antibodies anti-fibronectin; included that used for the experiments.
The secretion contained no fibronectin reactivity using any of the antibodies used neither by Western blot nor by ELISA. This demonstrates that the observed effect of the secretion in fibronectin assembly and secretion is due to its effect on the cells, not on direct deposition of ECM included in the extract.
The Snail's Secretion Downregulates Matrix Metalloproteinase Expression in Dermal Fibroblasts
Increased metalloproteinase expression has been associated to impaired wound healing and regeneration. To investigate if the secretion enhanced regeneration through the regulation of metalloproteinase expression, MMP expression was assayed by dermal fibroblasts in the presence of different concentrations of the secretion. The secretion significantly inhibited MMP-1 and MMP-2 expression, suggesting that limitation of MMP expression contributes to its regenerative properties.
Discussion
The secretion is naturally produced by the mollusk C. aspersa and bears regenerative properties in experimental acute radiodermatitis produced in a rat model [7] . Furthermore, application of the secretion twice daily for 3 months also results in a significant improvement of clinical and histopathological photoaging signs [5] . However, the molecular foundations of the beneficial effect of the secretion remained unknown. The cited report shows in vitro analysis of several possible contributions to the physiological effect of the snail's secretion.
First, it was found that the snail's secretion bear antioxidant activities as well as free radical scavenging capability. The role of oxidation in wound healing is controversial [11], but there is a clear correlation between enzymatic and non-enzymatic cutaneous antioxidants and its protection from ROS-mediated skin damage induced by UV radiation. Indeed, UV radiation can decrease endogenous antioxidant levels and lead to increased damage [12] . In these cases, antioxidant compounds can modulate abnormal remodeling after trauma or prevent or reverse clinical signs associated with photoaging secondary to ROS.
In addition, the snail's secretion promotes fibroblast survival and proliferation. Proliferation is essential for wound healing, since the formation of the scar relies not only on cell migration (i.e. invasion of the wound by border cells), but also on cell proliferation to replenish the tissue zones that provide the migrating cells invading the wound. The effect of the secretion was similar to that observed in dermal fibroblasts treated with bFGF [13]. Thus, it was hypothesized that the secretion might contain an FGF like activity responsible for fibroblast proliferation.
However, the fact that the secretion belongs to a mollusk impaired the analysis of bFGF, since the only kits for mammalian FGFs are currently available, and these did not recognize any FGF-like activity in the snail's secretion. Thus, the researchers devised an indirect strategy, adding well-characterized stabilizers and enhancers of bFGF to the snail's secretion to modulate its effect on proliferation. These included citrate [14–16] , which had no effect when added to the cultures alone (data not shown). However, in conjunction with the secretion, it boosted its pro-proliferative effect, suggesting that citrate enhanced the putative FGF like activity contained in the snail's secretion.
It was also found that the secretion increases ECM assembly when added alone or in conjunction with exogenously added fibronectin. This is a very important phenomenon during wound healing since matrix remodeling is a key step in fibroblast motility for wound healing and scar formation.
In fact, matrix secretion and rearrangement is absolutely required during in vitro wound healing assays, since scratching the surfaces also depletes ECM from the wound, which is required for lamellipodial extension and net cell migration into the wound. The first obvious conjecture was that the secretion contained fibronectin. However, none of the antibodies assayed against fibronectin recognized any component of the secretion. However, this provided an excellent internal control since these antibodies could not detect snail's secretion added to the cultures, and increases observed are likely to be due to increased fibronectin expression and/or secretion by the cultures. Indeed, bFGF has been shown to increase fibronectin fibrillogenesis [17] . The effect of snail secretion on fibronectin assembly seems more dramatic as shown by enhanced bundling of fibronectin fibers, but its effect on secretion cannot be ruled out without more experimentation, which is underway in the researchers laboratory.
Another possible mechanism for fibronectin remodeling was an increase in integrin activation induced by the secretion. Indeed, integrin activation has been linked to matrix remodeling [18] . However, the secretion did not activate ß1 integrins by itself nor did it affect Mn 2+ -induced conformational changes, as determined by the use of HUTS-21, a conformation-dependent antibody (data not shown). This result suggests that the effect of the secretion on ECM assembly relies on mechanisms other that integrin-fibronectin
binding.
Finally, snail secretion has been shown to slightly inhibit the expression of MMP-1 and MMP-2.
ECM proteinases are upregulated during wound healing and scar formation, and they are believed to be essential for wound closure and scar formation [19, 20] . This effect of the secretion is apparently at odds with the fact that bFGF enhances MMP-1 and MMP-2 expression [21, 22]. We speculate that this apparent contradiction can be explained by the snail's secretion containing at least two active principles, an FGF-like activity and an inhibitor of MMP expression.
Alternatively, the secretion could enhance the expression of TIMPs (tissue inhibitor of metalloproteinases). This can also help explain this dual effect of the secretion, since bFGF has been shown to inhibit or increase TIMP expression depending on the cell model [23–25] . This is a very interesting topic, and the presence of TIMP-like molecules; stimulation of TIMP expression or the presence of other non-related MMP inhibitors in the secretion is being currently studied in the laboratory.
Together, the data provides evidence for the molecular mechanism underlying the observed regenerative effect of snail secretion and open an interesting avenue of research aiming to clarify these effects and isolate the active principles responsible of the effects herein described.
The skin cream presented at this website and made with the escargot serum is designed to gently ditch out damaged cells of your skin regularly. Not only will you slough off that dulling, dead, outermost layer of skin that is less than a micron thick, regularly. But, you will keep the circulation flowing in your body alive, which will rejuvenate you and your skins vibrancy.
This can be achieved with ONE complete and balanced skin cream made with the natural substance that gently dissolves or "digests" damaged and worn out cells and triggers the regeneration of healthy skin cells – Bioskincare –
Bioskincare is a 100% pure skin cream that regenerates your skin and also works to keep it moisturized, vigorous, smooth, kissable and resilient. It provides results on the appearance of fine lines, wrinkles, redness, acne, dark sun spots, facial blemishes, – even acne scarring, surgical scars and body stretch marks that you have lived with a long time will appear softer and be less noticeable. This skin cream mobilizes your body's own healing resources to maximize the effectiveness of the biological ingredients it supplies.
The tissue-regenerating effect of the snail serum is notable as it has been attested by studies done with a topical product including the biological ingredient at the Coaniquem Burn Center Foundation, a Non Profit Children's Burn Hospital in Santiago, Chile.
Also confirmed by clinical studies done in Spain, where the ingredient in a topical formulation was applied for the treatment of burns, blisters and damage to skin due to radiotherapy to 100 patients undergoing radiotherapy or that had completed radiation treatment the previous month at the Hospital Ramon y Cajal in Madrid.
If you have burn scars or scar marks on your face, hands, arms or other places, and you want to heal your scars and restore your skin to its original beauty, then you'll want to treat your scars with BIOCUTIS.
The secretion also contains antimicrobial peptides and triggers the proliferation of antimicrobial peptides which protect the snail from being affected by attacks from opportunistic micro-organisms always ready to intrude when skin is injured. Now, isn't that truly amazing! As a result, snails never suffer from skin infections – can you imagine?
Besides healing burn wounds and diminishing scars the immune serum of the snails has interesting “side” effects. When you put it on skin, you can observe immediate improvements in skin texture, tone and color. If you keep applying it, you will see structural changes (increase collagen production) with diminution of wrinkles. Minor cuts and abrasions heal very quickly. Irritated red areas seem to disappear.
Biocutis creams can also be of special help if you have sensitive skin, dry skin, older blemishes or colored skin blemishes.
You can order BIOCUTIS natural skin care products at Amazon.com or at Biocutis.com
How It Works? - Slowly, by patiently applying the cream twice a day every day on the area you wish to protect or heal. Two months is enough to see significant results.
Our products work if you use them in a way similar to how another surprising mollusk, the oyster, coats an irritant —which causes a state of inflammation triggered by cell lining damage— by secreting a smooth, lustrous substance called nacre, little by little, around the irritant to prevent it from disrupting its soft tissues. In the process you will also achieve something as precious as a beautiful Pearl: soft, beautiful looking, healthy skin.
Our products are not endorsed by the Memorial Sloan-Kettering Cancer Center in New York but their published research validates the regenerative properties of the immune serum conclusively.
All our products are safe for children and moms-to-be. The cream relieves baby's diaper rash & eczema and softens and moisturizes rough areas on knees and cracked feet.
“Bioskincare has done a fantastic job for my facial scars. I never thought that something this wonderful could actually live up to it's promises. It sounded like it was too good to be true at first, but I thought I would give it a try anyway. Well needless to say this is my second order of two jars and I absolutely LOVE IT. I saw results on my acne scars in about three weeks time. I can't wait to get my next order..... This stuff is great!!!!!! THANK YOU SO MUCH!!!!! Courtney Barth”. Ohio, USA
“I have been using Bioskincare cream for two months now and I can’t believe the difference! I’m excited to wake up every morning and see the changes in my skin.” Kara Potts. Salt Lake City, UT, US.
“This cream works great. It seems so natural and potent. I put the cream on the back of my neck after cutting my braids off and it removed my bumps and scars within 2 weeks. I also use it on the little bumps on my forehead and it does wonders”. Chris Roberson. CA, USA
“I got to say how I love how easily absorbed this cream is. It goes right into your skin and does not leave that shiney or greasy look or feel on your skin. This is the only skin lotion that I have found like that. Everything I have tried leaves me either shiney or greasy which I hate”. Diane E. WY, USA
“I've been using Bioskincare Cream for just over two months and there is a noticeable difference with my skin. My usually extremely acne prone skin has calmed down a LOT, and though I do still get outbreaks, they usually disappear when I apply more of the product on. I'm now trying to fade out my facial pigmentation, dark spots caused by the sun I think. Fingers crossed that this miracle cream can do that as well! ” Michelle Doran. Hong Kong.
“My dermatologist told me there was really nothing I could do for my Keloid scars. Even with surgery there is a good chance the scarring would return. After using Bioskincare, the improvement I’ve seen has been nothing short of a miracle!” David Starks, New York.
“I have been clearing up a number of Actinic Keratosis with Folic Acid, B12, B17 and Aloe vera gel over almost 10 years. The Bioskin Cream appears as though it will clear the remains up within 2-3 weeks. A significant lesion appeared as a result of the Aloe Vera etc treatment and although it has gradually been diminishing, there has been far greater change in 1 week with Bioskincare than the last 9 months. Peter Melvelle“. NSW, Australia
“I have had brain surgery and two cervical disks transplants. At the rate that this product is working, people won't even be able to tell in under a year. Now that's amazing“. Janet M. Liston. Idaho, USA.
“My dermatologist was totally out of resources for me when he told me about Bioskincare. It is the only thing that has made my awful facial rash calm down. It is not totally gone yet, but after just one tub of Bioskincare, it is 60% better. I hope it will soon be 100%. Thank you! Vanessa Kuhn”. IN, USA.
“I love your product. I have been using it for 3 months now. I am allergic to most products that make skin look more youthful and yours has no reaction whatsoever. Plus my skin is great....it glows and I barely have to wear any make up! Thanks for a great product. Susan Miller”. Texas, USA
“I have used this product to treat acne and inflammation and it is the best out there. I highly recommend it. I love the cream. It's excellent even for very sensitive skin such as mine. It literally stops a breakout and decreases inflammation overnight!” Stacey Baptiste. New York
“This product is reconditioning my facial skin. It reduces the size of my pores and I find that it really speeds exfoliation and skin renewal. It has partially removed scarring on my face. I have also used it on my forearms to lessen dark spots from the sun and to improve scarring. Lynn Nelson”. IA, USA
“I have been using BIOSKINCARE on my son for 5 weeks and my husband and I have noticed a dramatic difference in the texture and appearance of his skin. My son is two and a half years old and suffered a third degree burn to his right shoulder after pulling a kettle of boiling over himself when he was 20 months old! Thank you for your miraculous cream and for putting a smile back on our faces again! You have created wonders for us so far, hence I feel devoted to you! With many thanks and best wishes! Maeve Quinn”. United Kingdom.
“This is order no. 3 --send jars 5 and 6 quickly!! I have faithfully been using your Bioskin cream twice a day for the past 9 months. I love it and the way it has made my facial skin smoother, brighter, younger looking! Debora Cousins” South Carolina, USA
“I can't believe how well your product works. When I ordered for the first time for acne scars I was skeptical about any results. Let me say that this is my 5th order. I have never ordered anything that has worked as well as the BIOSKINCARE cream. I had major acne scars and discoloration on my back. My back is almost at 90% recovery in 7 months of use. I estimate that 4 more jars should do the trick. My friend also tried a jar and now is ordering his own. Thank you very much. Kindest Regards” Ash Hassab. Illinois, USA
“I am 21 years old and in the passed year, for some unknown reason, have began breaking out and broke my bank account trying to stop it. You name it, I've tried it: ProActiv, $20 face wash, masks, peels, prescriptions, ointments and all without success. My skin is insanely sensitive and I was developing scars which, in my opinion, are worse than the acne itself because they take forever to fade. But until I could control the break outs -I was told- I couldn't do anything to stop the scarring. I found BIOSKINCARE online and thought, why not? The theory makes sense. And it's nice to see an almost all-natural product on the market because, more than anything, my skin is too sensitive to take the chemicals in other treatments. Instantly my skin was softer and smoother and after 2 months of use, the breakouts have completely stopped and the scars have faded considerably. My skin feels great and I feel great about it! And I feel confident buying BIOSKINCARE online, the customer service has been wonderful. Thanks a million!” F.S. Hafford, Canada.
“Have definitely noticed a difference on my skin since using the cream. Its helped my facial acne scars. Almost finished my first jar never thought I would be buying more as I did not believe it would work. However I think that using this product over a period of time it will really help my appearance. Thank you. W Anderson. Co. Antrim” Ireland.
Natural Scar Treatment Remedies
Our products are natural remedies for the removal and prevention of scars, and for other problematic skin condition as well as for routine skin care. They are made with natural ingredients and manufactured in a state of the art Cosmetic Laboratory in the USA. Safe for children, moms-to-be and breast feeding mothers.
We encourage you to read all about the ingredients, the particular molecules they are composed of, and their properties here: scar cream ingredients.
The discoverer of a natural healing substance cannot patent the phenomenon
The main ingredient in the Biocutis line of products is a complex natural compound that cannot be replicated in even the most sophisticated laboratory on Earth. Because it is a naturally occurring compound and not a man-made substance it cannot be patented. This would only be possible if it were an isolate from a natural substance or a man made ingredient achieved through chemical reactions. Thus, by its very nature no one can claim exclusive rights of use granted by a patent of invention.
Interestingly, even though there is no incentive to do research about the snail secretions because nobody can claim exclusive rights of use and market it broadly to recover its own investment in research, the supporting evidence has led to studies through academic sponsorship that position the immune serum as a complex of macromolecules that belong in regenerative medicine together with stem cell research.
And it may have many impacts beyond healing of skin injuries or wounds & aging skin care. This is not mere cosmetics – this is core cellular physiology. And how grand it is (for a change) that with it skin science gets to be on the forefront of research rather than on the back burner.
And wounds, by the way, don’t have to be acute injuries like cuts or bruises. Every time you go out into the sun (especially if unprotected) your skin undergoes injury. The DNA in your skin cells is damaged. Chemicals are released. Some of those cells will be repaired. Some will die. But repeated insult and repair leads to photo-aging. Dark spots, wrinkles, sags, dryness, etc. Add to that some intrinsic (genetically programmed) aging. With chronic, repeated injury there are changes that take place in the skin (subsurface scarring).
In the future you will be able to re-invigorate your skin’s own healing mechanisms, rid yourself of chronically damaged tissues, and rebuild with fresh new cells. Not with exogenous materials from other sources (be they plants, animals, or other humans) but with your body’s own innate healing mechanisms. Imagine little nano machines migrating into your dermal layers and repairing them, inside out. Injecting mitochondria where needed. Reprogramming your skin cells to repair and rejuvenate you over and over again... In the meantime routinely coat your skin with BIOCUTIS for a lifetime of healthy skin and graceful aging.
If this is your first time using Biocutis we are offering you a 100% no-risk guarantee. If you use one of our products twice a day for one month and don’t get significant improvements you can simply return the empty jar and we will refund your money. Simple as that.
